Human Adult Neurogenesis: Evidence and Remaining Questions

Gerd Kempermann; Fred H Gage; Ludwig Aigner; Hongjun Song; Maurice A Curtis; Sandrine Thuret; H Georg Kuhn; Sebastian Jessberger; Paul W Frankland; Heather A Cameron; Elizabeth Gould; Rene Hen; D Nora Abrous; Nicolas Toni; Alejandro F Schinder; Xinyu Zhao; Paul J Lucassen; Jonas Frisén

doi:10.1016/j.stem.2018.04.004

Human Adult Neurogenesis: Evidence and Remaining Questions

Cell Stem Cell. 2018 Jul 5;23(1):25-30. doi: 10.1016/j.stem.2018.04.004. Epub 2018 Apr 19.

Authors

Gerd Kempermann¹, Fred H Gage², Ludwig Aigner³, Hongjun Song⁴, Maurice A Curtis⁵, Sandrine Thuret⁶, H Georg Kuhn⁷, Sebastian Jessberger⁸, Paul W Frankland⁹, Heather A Cameron¹⁰, Elizabeth Gould¹¹, Rene Hen¹², D Nora Abrous¹³, Nicolas Toni¹⁴, Alejandro F Schinder¹⁵, Xinyu Zhao¹⁶, Paul J Lucassen¹⁷, Jonas Frisén¹⁸

Affiliations

¹ German Center for Neurodegenerative Diseases (DZNE) Dresden and CRTD (Center for Regenerative Therapies Dresden), Technische Universität Dresden, Dresden, Germany. Electronic address: gerd.kempermann@dzne.de.
² Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA. Electronic address: gage@salk.edu.
³ Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria.
⁴ Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
⁵ Department of Anatomy and Medical Imaging and Centre for Brain Research, The University of Auckland, Auckland, New Zealand.
⁶ King's College London, Institute of Psychiatry, Psychology & Neuroscience, Department of Basic and Clinical Neuroscience, London, UK.
⁷ University of Gothenburg, Institute for Neuroscience and Physiology, Section for Clinical Neuroscience, Gothenburg, Sweden; Charité - Universitätsmedizin Berlin, Neurocure Cluster of Excellence, Berlin, Germany.
⁸ HiFo / Brain Research Institute, University of Zurich, Zurich, Switzerland.
⁹ Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON M5GOA4, Canada.
¹⁰ Section on Neuroplasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
¹¹ Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
¹² Departments of Neuroscience and Psychiatry, Columbia University, New York, NY, USA.
¹³ Neurocentre Magendie, INSERM U1215, Bordeaux, France.
¹⁴ Lausanne University Hospital, Department of Psychiatry, Center for Psychiatric Neurosciences, Lausanne, Switzerland.
¹⁵ Neuronal Plasticity Lab, Leloir Institute - CONICET, Buenos Aires, Argentina.
¹⁶ Waisman Center and Department of Neuroscience, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
¹⁷ Brain Plasticity group, Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, the Netherlands.
¹⁸ Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden. Electronic address: jonas.frisén@ki.se.

Abstract

Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.

Publication types

Review

MeSH terms

Adult
Hippocampus / cytology
Humans
Neurogenesis*
Neuronal Plasticity*
Neurons / cytology*

Abstract

Publication types

MeSH terms

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