Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits

Karen Lavi; Gilad A Jacobson; Kobi Rosenblum; Andreas Lüthi

doi:10.1016/j.celrep.2018.06.053

Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits

Cell Rep. 2018 Jul 10;24(2):278-283. doi: 10.1016/j.celrep.2018.06.053.

Authors

Karen Lavi¹, Gilad A Jacobson², Kobi Rosenblum³, Andreas Lüthi⁴

Affiliations

¹ Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland; Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 5290002, Israel; Sagol Department of Neurobiology, University of Haifa, Haifa 3498838, Israel.
² Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
³ Sagol Department of Neurobiology, University of Haifa, Haifa 3498838, Israel; Center for Gene Manipulation in the Brain, University of Haifa, Haifa 3498838, Israel.
⁴ Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland; Biozentrum, University of Basel, Basel 4056, Switzerland. Electronic address: andreas.luthi@fmi.ch.

PMID: 29996089
DOI: 10.1016/j.celrep.2018.06.053

Abstract

Avoidance of potentially toxic food by means of conditioned taste aversion is critical for survival of many animals. However, the underlying neuronal mechanisms are poorly understood. Here, using two-photon calcium imaging of defined gustatory cortex neurons in vivo, we show that conditioned taste aversion dynamically shifts neuronal population coding by stimulus-specific recruitment of neurons that project to the basolateral amygdala.

Keywords: BLA; CTA; associative learning; calcium imaging; conditioning; gustatory cortex.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amygdala / physiology*
Animals
Avoidance Learning / physiology*
Conditioning, Classical*
Imaging, Three-Dimensional
Male
Mice, Inbred C57BL
Nerve Net / physiology*
Taste / physiology*