Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2: Cardiovascular system

Experientia. 1986 Mar 15;42(3):292-7. doi: 10.1007/BF01942510.

Abstract

Urethane produces a level of surgical anesthesia characterized by preservation of a number of cardiovascular reflexes. When the proper route of administration is used, and the use of unnecessarily high doses is avoided, urethane anesthesia appears to be suitable for a number of investigations at cardiovascular level. However in certain types of studies involving pharmacological stimulation of peripheral adrenoceptors urethane affects markedly the magnitude of the response under study.

Publication types

  • Review

MeSH terms

  • Anesthesia*
  • Angiotensin II / pharmacology
  • Animals
  • Blood Pressure / drug effects
  • Calcium / pharmacology
  • Cardiac Output / drug effects
  • Cardiovascular Physiological Phenomena*
  • Cardiovascular System / drug effects
  • Heart Rate / drug effects
  • Isoproterenol / pharmacology
  • Microcirculation / drug effects
  • Muscle Contraction / drug effects
  • Muscle, Smooth, Vascular / physiology
  • Norepinephrine / pharmacology
  • Receptors, Adrenergic, alpha / physiology
  • Reflex / drug effects
  • Regional Blood Flow / drug effects
  • Stroke Volume / drug effects
  • Urethane / pharmacology*
  • Vasoconstriction / drug effects

Substances

  • Receptors, Adrenergic, alpha
  • Angiotensin II
  • Urethane
  • Isoproterenol
  • Calcium
  • Norepinephrine