Abstract
Urethane produces a level of surgical anesthesia characterized by preservation of a number of cardiovascular reflexes. When the proper route of administration is used, and the use of unnecessarily high doses is avoided, urethane anesthesia appears to be suitable for a number of investigations at cardiovascular level. However in certain types of studies involving pharmacological stimulation of peripheral adrenoceptors urethane affects markedly the magnitude of the response under study.
MeSH terms
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Anesthesia*
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Angiotensin II / pharmacology
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Animals
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Blood Pressure / drug effects
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Calcium / pharmacology
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Cardiac Output / drug effects
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Cardiovascular Physiological Phenomena*
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Cardiovascular System / drug effects
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Heart Rate / drug effects
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Isoproterenol / pharmacology
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Microcirculation / drug effects
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / physiology
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Norepinephrine / pharmacology
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Receptors, Adrenergic, alpha / physiology
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Reflex / drug effects
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Regional Blood Flow / drug effects
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Stroke Volume / drug effects
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Urethane / pharmacology*
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Vasoconstriction / drug effects
Substances
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Receptors, Adrenergic, alpha
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Angiotensin II
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Urethane
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Isoproterenol
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Calcium
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Norepinephrine