Building Models of Brain Disorders with Three-Dimensional Organoids

Neal D Amin; Sergiu P Paşca

doi:10.1016/j.neuron.2018.10.007

Building Models of Brain Disorders with Three-Dimensional Organoids

Neuron. 2018 Oct 24;100(2):389-405. doi: 10.1016/j.neuron.2018.10.007.

Authors

Neal D Amin¹, Sergiu P Paşca²

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
² Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA. Electronic address: spasca@stanford.edu.

PMID: 30359604
DOI: 10.1016/j.neuron.2018.10.007

Abstract

Disorders of the nervous system are challenging to study and treat due to the relative inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human brain organoids have the potential to recapitulate features of the human brain with greater complexity than 2D models and are increasingly being applied to model diseases affecting the central nervous system. Here, we review the use of human brain organoids to investigate neurological and psychiatric (neuropsychiatric) disorders and how this technology may ultimately advance our biological understanding of these conditions.

Publication types

Review

MeSH terms

Brain Diseases*
Humans
Organ Culture Techniques / methods*
Organoids* / growth & development