Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons

Nat Neurosci. 2019 Apr;22(4):642-656. doi: 10.1038/s41593-019-0349-8. Epub 2019 Mar 11.

Abstract

The lateral hypothalamic area (LHA) coordinates an array of fundamental behaviors, including sleeping, waking, feeding, stress and motivated behavior. The wide spectrum of functions ascribed to the LHA may be explained by a heterogeneous population of neurons, the full diversity of which is poorly understood. We employed a droplet-based single-cell RNA-sequencing approach to develop a comprehensive census of molecularly distinct cell types in the mouse LHA. Neuronal populations were classified based on fast neurotransmitter phenotype and expression of neuropeptides, transcription factors and synaptic proteins, among other gene categories. We define 15 distinct populations of glutamatergic neurons and 15 of GABAergic neurons, including known and novel cell types. We further characterize a novel population of somatostatin-expressing neurons through anatomical and behavioral approaches, identifying a role for these neurons in specific forms of innate locomotor behavior. This study lays the groundwork for better understanding the circuit-level underpinnings of LHA function.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cluster Analysis
  • Female
  • GABAergic Neurons / metabolism
  • Gene Expression Profiling / methods
  • Glutamic Acid / metabolism
  • Hypothalamic Area, Lateral / metabolism*
  • Male
  • Mice, Inbred C57BL
  • Neurons / metabolism*
  • Sequence Analysis, RNA / methods
  • Single-Cell Analysis / methods*
  • Transcriptome*

Substances

  • Glutamic Acid