Abstract
Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrillary tangles in brains from patients with Alzheimer's disease. In addition, regions and layers that normally contain a high density of such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few remaining immunoreactive cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / metabolism*
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Alzheimer Disease / pathology
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Antibodies, Monoclonal*
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Cerebral Cortex / analysis*
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Cerebral Cortex / pathology
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Hippocampus / analysis
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Hippocampus / pathology
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Humans
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Intermediate Filament Proteins / analysis*
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Intermediate Filament Proteins / immunology
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Middle Aged
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Neurofibrils / analysis
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Neurofibrils / pathology
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Neurofilament Proteins
Substances
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Antibodies, Monoclonal
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Intermediate Filament Proteins
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Neurofilament Proteins