Abstract
The Ca-dependence of spike repolarization and afterhyperpolarizations (AHPs) in Ca1 pyramidal cells, was tested with intracellular electrodes containing the Ca buffers EGTA or 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA). EGTA blocked only the slow AHP; but the fast-acting Ca chelator BAPTA also inhibited spike repolarization and the fast AHP. This supports the hypothesis that a fast Ca-activated'K-current contributes to spike repolarization.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Calcium / pharmacology*
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Chelating Agents / pharmacology*
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Egtazic Acid / pharmacology*
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Evoked Potentials / drug effects
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Hippocampus / drug effects
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Hippocampus / physiology*
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Neurons / drug effects
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Neurons / physiology*
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Pyramidal Tracts / drug effects
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Pyramidal Tracts / physiology
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Rats
Substances
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Chelating Agents
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Egtazic Acid
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1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid
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Calcium