A Light Touch on Sociability

Nuria Domínguez-Iturza; Claudia Bagni

doi:10.1016/j.cell.2019.07.022

A Light Touch on Sociability

Cell. 2019 Aug 8;178(4):769-771. doi: 10.1016/j.cell.2019.07.022.

Authors

Nuria Domínguez-Iturza¹, Claudia Bagni²

Affiliations

¹ Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
² Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. Electronic address: claudia.bagni@unil.ch.

PMID: 31398332
DOI: 10.1016/j.cell.2019.07.022

Abstract

Autism spectrum disorder (ASD) is prevalent, complex, and heterogeneous, and currently there is no cure. Identifying shared mechanisms across the ASD spectrum is of utmost importance for therapeutic intervention. Orefice et al. show that tackling the GABA_A receptor pathway in the peripheral somatosensory system in various ASD mouse models rescues core ASD-like phenotypes.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Autism Spectrum Disorder*
Interneurons
Mice
Phenotype
Receptors, GABA-A

Substances

Receptors, GABA-A