Abstract
Depolarizing responses of Purkinje and granule cells to excitatory amino acid receptor agonists were recorded from rat cerebellar slices at various stages of postnatal maturation using a gap technique. No major developmental changes in relative potency or efficacy of kainate and quisqualate were observed. However, Purkinje and granule neurones both became less responsive to N-methyl-D-aspartate (NMDA) with age, most dramatically so between 14 and 21 days. This transient chemosensitivity to NMDA may reflect a special role of the NMDA receptor system in cerebellar development.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aging
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Animals
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / pharmacology
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Cerebellum / cytology
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Cerebellum / drug effects
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Cerebellum / growth & development*
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Convulsants / pharmacology
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In Vitro Techniques
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Kainic Acid / pharmacology
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Membrane Potentials / drug effects
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N-Methylaspartate
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Neurons / drug effects
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Neurons / physiology*
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Oxadiazoles / pharmacology
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Purkinje Cells / drug effects
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Purkinje Cells / physiology*
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Quisqualic Acid
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Rats
Substances
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Convulsants
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Oxadiazoles
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Aspartic Acid
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N-Methylaspartate
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Quisqualic Acid
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Kainic Acid