Dopamine and preparatory behavior: I. Effects of pimozide

Behav Neurosci. 1987 Jun;101(3):352-60. doi: 10.1037//0735-7044.101.3.352.

Abstract

The involvement of dopaminergic systems in appetitive and ingestive feeding behaviors was investigated in two experiments. Conditioned preparatory responses to a conditional stimulus (CS+) signaling delivery of a meal were attenuated in rats by doses of 0.4 and 0.6 mg/kg of the dopamine receptor antagonist pimozide. In contrast, animals responded in a normal fashion following the delivery of food. Similarly, in a separate study, the 20-min free-feeding intake of liquid diet by rats that had been deprived of food for 23 hr was unaffected by doses of pimozide as high as 0.6 mg/kg. These findings are consistent with the involvement of dopamine in the production of preparatory behaviors elicited by incentive stimuli.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Appetitive Behavior / drug effects*
  • Brain / drug effects
  • Conditioning, Classical / drug effects
  • Consummatory Behavior / drug effects
  • Cues
  • Dopamine / physiology*
  • Male
  • Pimozide / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Reaction Time / drug effects
  • Receptors, Dopamine / drug effects*

Substances

  • Receptors, Dopamine
  • Pimozide
  • Dopamine