Primary kindling of generalized seizures with amygdaloid stimulation facilitated the subsequent kindling of generalized seizures with neocortical stimulation. Similarly, initial kindling of generalized seizures with anterior neocortical stimulation facilitated the kindling of generalized amygdaloid seizures. Unexpectedly, there were striking differences in the reliability with which seizures could be triggered by amygdaloid and neocortical stimulation. The results support the idea that there is a single mechanism that is responsible for seizure generalization.