Abstract
We examined high-affinity, sodium-dependent binding of hemicholinium-3 to brain membranes. Binding, with Kd of about 3 nM, was highest in corpus striatum, intermediate in cerebral cortex and hippocampus, and low in cerebellum. Treatment with physostigmine in vivo reduced binding in all regions without affecting apparent affinity.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / metabolism*
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Cerebellum / metabolism
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Cerebral Cortex / metabolism
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Corpus Striatum / metabolism
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Hemicholinium 3 / metabolism*
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Hippocampus / metabolism
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Male
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Membranes / metabolism
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Physostigmine / pharmacology*
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Rats
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Rats, Inbred Strains
Substances
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Hemicholinium 3
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Physostigmine