Abstract
Somatostatin-28 (SS-28) and desAA1,2,4,5,12,13[D-Trp8]somatostatin (ODT8-SS), but not somatostatin-14, given intracerebroventricularly, but not when given iv, inhibit stress-induced pituitary ACTH and adrenomedullary epinephrine secretion in rats. The elevation of ACTH after tail-suspension stress is totally prevented by iv administration of antisera raised against corticotropin-releasing factor (CRF). SS-28 and ODT8-SS do not inhibit CRF-induced ACTH secretion in vivo or in vitro. These results are consistent with the hypothesis that SS-28 and ODT8-SS prevent stress-induced ACTH secretion by inhibition of CRF release.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adrenocorticotropic Hormone / metabolism*
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Animals
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Brain / metabolism
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Corticotropin-Releasing Hormone / metabolism
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Epinephrine / blood
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Injections, Intravenous
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Injections, Intraventricular
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Male
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Norepinephrine / blood
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Peptide Fragments / administration & dosage
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Peptide Fragments / pharmacology*
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Rats
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Rats, Inbred Strains
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Somatostatin / administration & dosage
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Somatostatin / pharmacology*
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Somatostatin-28
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Stress, Physiological / metabolism*
Substances
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Peptide Fragments
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Somatostatin
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somatostatin, octapeptide-Trp(8)-
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Somatostatin-28
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Adrenocorticotropic Hormone
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Corticotropin-Releasing Hormone
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Norepinephrine
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Epinephrine