Abstract
The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Behavior, Animal / drug effects*
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Brain / metabolism
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Cyclazocine / pharmacology*
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Hydromorphone / pharmacology*
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In Vitro Techniques
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Ketamine / pharmacology*
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Male
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Phenazocine / analogs & derivatives*
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Phenazocine / pharmacology
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Phencyclidine / pharmacology*
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Rats
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Rats, Inbred Strains
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Receptors, Opioid / drug effects
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Receptors, Opioid / physiology*
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Stereoisomerism
Substances
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Receptors, Opioid
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Ketamine
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SK&F 10047
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Phenazocine
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Phencyclidine
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Cyclazocine
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Hydromorphone