Immunocytochemical localization of glutamic acid decarboxylase in monkey striate cortex

Nature. 1981 Aug 13;292(5824):605-7. doi: 10.1038/292605a0.

Abstract

Neuronal cell bodies and synaptic terminals positive for glutamic acid decarboxylase, the enzyme responsible for synthesizing gamma-amino butyric acid, have been located by immunocytochemical staining in all layers of the macaque monkey cortex. In layers II and III the staining pattern of periodic dots is identical with that seen in sections stained for cytochrome oxidase. The rows of dots run parallel with the ocular dominance columns, suggesting that the labelled neurones are preferentially related to each eye.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carboxy-Lyases / metabolism*
  • Electron Transport Complex IV / metabolism
  • Glutamate Decarboxylase / immunology
  • Glutamate Decarboxylase / metabolism*
  • Immunoenzyme Techniques
  • Macaca / anatomy & histology*
  • Macaca fascicularis / anatomy & histology*
  • Nerve Endings / enzymology
  • Visual Cortex / cytology
  • Visual Cortex / enzymology*

Substances

  • Electron Transport Complex IV
  • Carboxy-Lyases
  • Glutamate Decarboxylase