Abstract
Serotonin and LSD hyperpolarized serotonergic dorsal raphe neurons in rat midbrain slices; the hyperpolarizations were accompanied by a decrease in input resistance, suggesting an increase in potassium conductance as one possible mechanism. Reversal potentials for serotonin and LSD-induced hyperpolarizations showed a shift of approximately 18 mV for a two-fold change in extracellular potassium concentration; this shift was close to that predicted by the Nernst equation for a potassium-dependent conductance.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Brain Stem / drug effects*
-
In Vitro Techniques
-
Ion Channels / drug effects*
-
Lysergic Acid Diethylamide / pharmacology*
-
Male
-
Membrane Potentials / drug effects
-
Potassium / metabolism*
-
Raphe Nuclei / drug effects*
-
Raphe Nuclei / physiology
-
Rats
-
Serotonin / pharmacology*
-
Serotonin / physiology
-
Synaptic Transmission
Substances
-
Ion Channels
-
Serotonin
-
Lysergic Acid Diethylamide
-
Potassium