Modification of an analgesy meter for paw-pressure antinociceptive testing in neonatal rats

J Pharmacol Methods. 1984 Dec;12(4):255-8. doi: 10.1016/0160-5402(84)90011-1.

Abstract

A modification to a commercially available analgesy meter is described. This modification provides more consistent responses when studying antinociception in neonatal rats using the paw- or tail-pressure tests. The modification is simple and inexpensive and will be especially useful for developmental studies.

MeSH terms

  • Aging
  • Analgesics / pharmacology*
  • Animals
  • Animals, Newborn
  • Cyclazocine / analogs & derivatives
  • Cyclazocine / pharmacology
  • Drug Evaluation, Preclinical / instrumentation
  • Ethylketocyclazocine* / analogs & derivatives*
  • Foot / physiology
  • Pressure
  • Rats
  • Tail / physiology

Substances

  • Analgesics
  • Ethylketocyclazocine
  • ketazocine
  • Cyclazocine