Abstract
1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was administered via the intraperitoneal route to squirrel monkeys. Akinesia, rigidity and hypophonia were seen after repeated doses of 2 mg/kg. Postural tremor was present in one animal. Neuropathologic examination revealed cell loss restricted to the zona compacta of the substantia nigra. MPTP appears effective in producing an animal model for Parkinson's disease in the squirrel monkey, and may be one of the more selective neurotoxins described to date.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Animals
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Antiparkinson Agents / therapeutic use
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Brain Diseases / chemically induced*
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Brain Diseases / drug therapy
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Brain Diseases / pathology
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Disease Models, Animal
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Microscopy, Electron
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Parkinson Disease
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Pyridines / toxicity*
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Saimiri
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Substantia Nigra* / ultrastructure
Substances
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Antiparkinson Agents
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Pyridines
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine