Abstract
The ability of cholinergic ligands to regulate neuronal alpha-bungarotoxin receptor number was studied in dissociated monolayer cultures of embryonic chick ciliary ganglion neurons. Carbamylcholine and nicotine, but not D-tubocurarine, caused a loss of 25% of the surface [125I]alpha-bungarotoxin receptors within 1 h at 37 degrees C. This receptor loss occurred without change in affinity for [125I]alpha-bungarotoxin, was temperature-sensitive and was prevented by co-incubation with D-tubocurarine.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bungarotoxins / metabolism
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Carbachol / pharmacology*
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Chick Embryo
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Ganglia, Parasympathetic / drug effects*
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Ganglia, Parasympathetic / metabolism
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Kinetics
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Nicotine / pharmacology*
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Receptors, Cholinergic / drug effects*
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Receptors, Cholinergic / metabolism
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Receptors, Nicotinic*
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Tubocurarine / pharmacology
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alpha7 Nicotinic Acetylcholine Receptor
Substances
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Bungarotoxins
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Receptors, Cholinergic
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Receptors, Nicotinic
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alpha7 Nicotinic Acetylcholine Receptor
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Nicotine
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Carbachol
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Tubocurarine