Abstract
The present study investigates the expression of a tyrosine kinase receptor (trkB), its specific ligands brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) mRNAs in the striatum after seizures. The result showed an increase of trkB mRNA expression, both with and without tyrosine kinase domain, in the caudate-putamen and nucleus accumbens, but not in the globus pallidus. This increase peaked 3 h after treatment, and returned to normal levels by 12 h. The BDNF and NT-4 mRNAs showed no change at any time. In conclusion, the widespread and massive trkB mRNA induction after abnormal neuronal activity suggests local trophic support for this receptor, and a potential role in basal ganglia diseases involving non-dopaminergic components.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain-Derived Neurotrophic Factor
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Corpus Striatum / metabolism*
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Gene Expression
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Male
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Nerve Growth Factors / biosynthesis*
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Nerve Growth Factors / pharmacology*
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Nerve Tissue Proteins / biosynthesis*
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Pilocarpine / pharmacology
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Protein-Tyrosine Kinases / biosynthesis
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Protein-Tyrosine Kinases / genetics
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RNA, Messenger / biosynthesis
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RNA, Messenger / metabolism*
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Rats
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Rats, Wistar
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Receptor Protein-Tyrosine Kinases / biosynthesis*
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Receptor Protein-Tyrosine Kinases / genetics
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Seizures / metabolism*
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Time Factors
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Up-Regulation
Substances
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Brain-Derived Neurotrophic Factor
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Nerve Growth Factors
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Nerve Tissue Proteins
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RNA, Messenger
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Pilocarpine
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Protein-Tyrosine Kinases
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Receptor Protein-Tyrosine Kinases
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neurotrophin 4