Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death

Eur J Pharmacol. 1994 Apr 11;256(1):109-12. doi: 10.1016/0014-2999(94)90624-6.

Abstract

(2S,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist of subtypes 2 and 3 of metabotropic glutamate receptors (mGluR2 or 3), protected cultured cortical neurons against excitotoxicity induced either by a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As a neuroprotective agent, DCG-IV was much more potent than the mixed agonists 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) or (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-CCG-I), suggesting a neuroprotective role for mGluR2 or 3 against excitotoxic neuronal death.

MeSH terms

  • 1-Methyl-3-isobutylxanthine / pharmacology
  • Amino Acids, Dicarboxylic / pharmacology
  • Animals
  • Cell Death / drug effects
  • Cells, Cultured
  • Cerebral Cortex / cytology
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism
  • Cyclic AMP / biosynthesis
  • Cycloleucine / analogs & derivatives
  • Cycloleucine / pharmacology
  • Cyclopropanes / pharmacology*
  • Glycine / analogs & derivatives*
  • Glycine / pharmacology
  • Kainic Acid / antagonists & inhibitors
  • Kainic Acid / toxicity
  • Mice
  • N-Methylaspartate / antagonists & inhibitors
  • N-Methylaspartate / toxicity
  • Neurons / drug effects*
  • Neurons / metabolism
  • Neurotoxins / pharmacology
  • Phosphatidylinositols / metabolism
  • Receptors, Metabotropic Glutamate / drug effects*

Substances

  • Amino Acids, Dicarboxylic
  • Cyclopropanes
  • Neurotoxins
  • Phosphatidylinositols
  • Receptors, Metabotropic Glutamate
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane
  • 2-(2,3-dicarboxycyclopropyl)glycine
  • (alpha-carboxycyclopropyl)glycine
  • N-Methylaspartate
  • Cyclic AMP
  • Kainic Acid
  • 1-Methyl-3-isobutylxanthine
  • Glycine