Abstract
(2S,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist of subtypes 2 and 3 of metabotropic glutamate receptors (mGluR2 or 3), protected cultured cortical neurons against excitotoxicity induced either by a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As a neuroprotective agent, DCG-IV was much more potent than the mixed agonists 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) or (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-CCG-I), suggesting a neuroprotective role for mGluR2 or 3 against excitotoxic neuronal death.
MeSH terms
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1-Methyl-3-isobutylxanthine / pharmacology
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Amino Acids, Dicarboxylic / pharmacology
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Animals
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Cell Death / drug effects
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Cells, Cultured
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Cerebral Cortex / cytology
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Cerebral Cortex / drug effects
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Cerebral Cortex / metabolism
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Cyclic AMP / biosynthesis
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Cycloleucine / analogs & derivatives
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Cycloleucine / pharmacology
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Cyclopropanes / pharmacology*
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Glycine / analogs & derivatives*
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Glycine / pharmacology
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Kainic Acid / antagonists & inhibitors
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Kainic Acid / toxicity
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Mice
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N-Methylaspartate / antagonists & inhibitors
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N-Methylaspartate / toxicity
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Neurons / drug effects*
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Neurons / metabolism
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Neurotoxins / pharmacology
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Phosphatidylinositols / metabolism
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Receptors, Metabotropic Glutamate / drug effects*
Substances
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Amino Acids, Dicarboxylic
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Cyclopropanes
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Neurotoxins
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Phosphatidylinositols
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Receptors, Metabotropic Glutamate
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Cycloleucine
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1-amino-1,3-dicarboxycyclopentane
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2-(2,3-dicarboxycyclopropyl)glycine
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(alpha-carboxycyclopropyl)glycine
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N-Methylaspartate
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Cyclic AMP
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Kainic Acid
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1-Methyl-3-isobutylxanthine
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Glycine