Abstract
To evaluate the effect of social crowding stress on the CRH and vasopressin-induced hypothalamic-pituitary-adrenocortical (HPA) response, both those neuropeptides were administered intracerebroventricularly and intraperitoneally to rats crowded for 3 days. Crowding stress did not affect the corticosterone response to CRH given by either route (1 micrograms i.c.v. or 2 micrograms/kg i.p.) but totally abolished or considerably diminished the response to vasopressin given i.p. (5 micrograms/kg) or i.c.v. (5 micrograms), respectively. Social crowding stress considerably impairs central vasopressin but does not change the CRH-system involved in the HPA stimulation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenocorticotropic Hormone / biosynthesis
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Adrenocorticotropic Hormone / blood
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Animals
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Corticosterone / biosynthesis
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Corticosterone / blood
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Corticotropin-Releasing Hormone / administration & dosage
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Corticotropin-Releasing Hormone / pharmacology*
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Crowding / physiopathology*
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Hypothalamo-Hypophyseal System / drug effects
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Hypothalamo-Hypophyseal System / physiopathology*
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Injections, Intraperitoneal
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Injections, Intraventricular
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Male
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Pituitary-Adrenal System / drug effects
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Pituitary-Adrenal System / physiopathology*
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Rats
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Rats, Wistar
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Stimulation, Chemical
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Stress, Psychological / physiopathology*
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Vasopressins / administration & dosage
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Vasopressins / pharmacology*
Substances
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Vasopressins
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Adrenocorticotropic Hormone
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Corticotropin-Releasing Hormone
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Corticosterone