The bewildering number of GABAA receptor subunits, their regionally dependent expression in the brain, and their supernumerary expression in single cells present major challenges in studying the function of native GABAA receptors. Which subunit combinations actually exist in native neurons? In this mini-review, GABAA receptor subunit diversity is considered in light of using the wealth of "structure-function" information gained from studying recombinant receptor to predict the subunit composition and functional properties of native GABAA receptors.