Prevention by the cannabinoid antagonist, SR141716A, of cannabinoid-mediated blockade of long-term potentiation in the rat hippocampal slice

Br J Pharmacol. 1995 Jul;115(6):869-70. doi: 10.1111/j.1476-5381.1995.tb15889.x.

Abstract

Incubation of rat hippocampal slices in the presence of the synthetic cannabinoid (-)-11-OH-delta 8-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation (LTP). Slices co-incubated with both HU-210 (100 nM) and the cannabinoid antagonist, SR141716A (100 nM), exhibited tetanically induced LTP, comparable to control slices. Intriguingly, coincubation with HU-210 and SR141716A prevented the induction of the early, short-term phase of LTP.

MeSH terms

  • Animals
  • Cannabinoids / antagonists & inhibitors*
  • Hippocampus / drug effects*
  • Long-Term Potentiation / drug effects*
  • Memory
  • Piperidines / pharmacology*
  • Pyrazoles / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Receptors, Cannabinoid
  • Receptors, Drug / antagonists & inhibitors*
  • Receptors, Drug / drug effects*
  • Rimonabant
  • Time Factors

Substances

  • Cannabinoids
  • Piperidines
  • Pyrazoles
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Rimonabant