Effects of the competitive NMDA receptor antagonist CGP 37849 on performance of reference and working memory tasks by rats

Eur J Pharmacol. 1995 Jul 4;280(2):239-42. doi: 10.1016/0014-2999(95)00255-j.

Abstract

The effects of the competitive NMDA receptor antagonist CGP 37849 (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid) were tested in rats performing (1) a nonspatial working memory task, and (2) a reference memory task that was either partly or fully learnt. CGP 37849 attenuated accuracy in all three tests, suggesting that sensorimotor effects may obscure any drug effects on memory itself.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Amino-5-phosphonovalerate / analogs & derivatives*
  • 2-Amino-5-phosphonovalerate / pharmacology
  • Animals
  • Discrimination, Psychological / drug effects
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Male
  • Maze Learning / drug effects
  • Memory / drug effects
  • Memory, Short-Term / drug effects*
  • Psychomotor Performance / drug effects*
  • Rats
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*

Substances

  • Excitatory Amino Acid Antagonists
  • Receptors, N-Methyl-D-Aspartate
  • 2-amino-4-methyl-5-phosphono-3-pentenoic acid
  • 2-Amino-5-phosphonovalerate