Abstract
Signaling molecules with either attractive or repulsive effects on specific growth cones are likely to play a role in guiding axons to their appropriate targets. A chick brain glycoprotein, collapsin, has been shown to be a good candidate for a repulsive guidance cue. We report here the discovery of four new molecules related to collapsin in chick brains. All contain a semaphorin domain. One is structurally very similar to collapsin but is only 50% identical in its amino acid sequence. We have named it collapsin-2. The collapsin-related genes exhibit distinct but overlapping patterns of mRNA expression in the developing spinal cord and the developing visual system. This family of collapsin-related molecules could potentially act as repulsive cues toward specific neuronal populations.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Avian Proteins
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Base Sequence
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Brain / embryology*
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Brain / metabolism
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Brain Chemistry*
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Chick Embryo
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DNA, Complementary / chemistry
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DNA, Complementary / isolation & purification
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Extremities / embryology
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Gene Expression
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Glycoproteins / analysis*
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Glycoproteins / chemistry
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Glycoproteins / genetics
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Intercellular Signaling Peptides and Proteins
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Molecular Sequence Data
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Nerve Growth Factors / analysis*
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Optic Nerve / chemistry
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Optic Nerve / embryology
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RNA, Messenger / analysis
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Retina / chemistry
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Retina / embryology
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Semaphorin-3A
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Spinal Cord / chemistry
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Spinal Cord / embryology*
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Superior Colliculi / chemistry
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Superior Colliculi / embryology
Substances
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Avian Proteins
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DNA, Complementary
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Glycoproteins
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Intercellular Signaling Peptides and Proteins
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Nerve Growth Factors
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RNA, Messenger
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SEMA3D protein, Gallus gallus
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Semaphorin-3A
Associated data
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GENBANK/U28240
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GENBANK/U28241
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GENBANK/U28242
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GENBANK/U28243