Coexpression of trk family members and low-affinity neurotrophin receptors in rat dorsal root ganglion neurons

H Kashiba; K Noguchi; Y Ueda; E Senba

doi:10.1016/0169-328x(94)00249-e

Coexpression of trk family members and low-affinity neurotrophin receptors in rat dorsal root ganglion neurons

Brain Res Mol Brain Res. 1995 May;30(1):158-64. doi: 10.1016/0169-328x(94)00249-e.

Authors

H Kashiba¹, K Noguchi, Y Ueda, E Senba

Affiliation

¹ Department of Physiology, Kansai College of Oriental Medicine, Osaka, Japan.

PMID: 7609637
DOI: 10.1016/0169-328x(94)00249-e

Abstract

We examined the colocalization of trk family and low-affinity neurotrophin receptor (LANR) mRNAs by means of in situ hybridization histochemistry in rat dorsal root ganglion (DRG) neurons. About 35-40%, 5%, and 15-20% of DRG neurons were positive for trkA, trkB, and trkC mRNAs, respectively. Each member of the trk family was coexpressed with LANR. The trkB mRNA-expressing neurons essentially lacked trkA and trkC mRNAs, and most of trkA and trkC mRNAs-expressing neurons (85-90%) belonged to different subpopulations, suggesting that they are involved in different functions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cyclic AMP-Dependent Protein Kinases / biosynthesis
Cyclic AMP-Dependent Protein Kinases / genetics
Ganglia, Spinal / cytology
Ganglia, Spinal / enzymology*
Gene Expression
In Situ Hybridization
Male
Neurons / enzymology
Neurons / metabolism
Protein Kinase C / biosynthesis
Protein Kinase C / genetics
Protein-Tyrosine Kinases / biosynthesis*
Protein-Tyrosine Kinases / genetics
RNA, Messenger / metabolism*
Rats
Rats, Wistar

Substances

RNA, Messenger
Protein-Tyrosine Kinases
Cyclic AMP-Dependent Protein Kinases
Protein Kinase C