The effects of mammillary body lesions on delayed matching and delayed non-matching to place tasks in the mice

Behav Brain Res. 1995 Apr;68(1):45-52. doi: 10.1016/0166-4328(94)00158-c.

Abstract

This study was designed to investigate the effects of different recognition procedures on memory performance in Balb/c mice. To this end, mice were submitted to spontaneous or contingently reinforced delayed non-matching (DNMTP) and delayed matching (DMTP) to place tasks in a T-maze. Results indicate that mammillary bodies (MM)-lesioned subjects are significantly impaired in the DNMTP tasks at the long (6 h) but not the short (5 min) delays; in contrast, they did not exhibit deficits in the DMTP task, whatever the delay considered. We stress the importance of task difficulty as a major factor explaining the different effects of the lesion in the two tasks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Conditioning, Operant / physiology*
  • Food
  • Ibotenic Acid / toxicity
  • Male
  • Mammillary Bodies / anatomy & histology
  • Mammillary Bodies / physiology*
  • Memory / physiology
  • Mice
  • Mice, Inbred BALB C
  • Reinforcement, Psychology
  • Reward
  • Space Perception / physiology*

Substances

  • Ibotenic Acid