Abstract
Skeletal muscle differentiation entails the coupling of muscle-specific gene expression to terminal withdrawal from the cell cycle. Several models have recently been proposed which attempt to explain how regulated expression and function of myogenic transcription factors ensures that proliferation and differentiation of skeletal muscle cells are mutually exclusive processes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Cell Cycle / genetics
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Cell Cycle / physiology
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Cell Differentiation / genetics
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Cell Differentiation / physiology
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Helix-Loop-Helix Motifs / physiology
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Muscle, Skeletal / cytology*
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MyoD Protein / physiology
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Oncogene Proteins / physiology
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Rhabdomyosarcoma
Substances
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MyoD Protein
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Oncogene Proteins