Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal

A B Lassar; S X Skapek; B Novitch

doi:10.1016/0955-0674(94)90046-9

Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal

Curr Opin Cell Biol. 1994 Dec;6(6):788-94. doi: 10.1016/0955-0674(94)90046-9.

Authors

A B Lassar¹, S X Skapek, B Novitch

Affiliation

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.

PMID: 7880524
DOI: 10.1016/0955-0674(94)90046-9

Abstract

Skeletal muscle differentiation entails the coupling of muscle-specific gene expression to terminal withdrawal from the cell cycle. Several models have recently been proposed which attempt to explain how regulated expression and function of myogenic transcription factors ensures that proliferation and differentiation of skeletal muscle cells are mutually exclusive processes.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Cell Cycle / genetics
Cell Cycle / physiology
Cell Differentiation / genetics
Cell Differentiation / physiology
Helix-Loop-Helix Motifs / physiology
Muscle, Skeletal / cytology*
MyoD Protein / physiology
Oncogene Proteins / physiology
Rhabdomyosarcoma

Substances

MyoD Protein
Oncogene Proteins