The effect of central blockade of kappa-opioid receptors on neuropeptide Y-induced feeding in the rat

P D Lambert; J P Wilding; A A al-Dokhayel; S G Gilbey; S R Bloom

doi:10.1016/0006-8993(93)90493-7

The effect of central blockade of kappa-opioid receptors on neuropeptide Y-induced feeding in the rat

Brain Res. 1993 Nov 26;629(1):146-8. doi: 10.1016/0006-8993(93)90493-7.

Authors

P D Lambert¹, J P Wilding, A A al-Dokhayel, S G Gilbey, S R Bloom

Affiliation

¹ Division of Endocrinology and Metabolism, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

PMID: 7904531
DOI: 10.1016/0006-8993(93)90493-7

Abstract

Neuropeptide Y (NPY) and the endogenous kappa-opioid receptor ligand, dynorphin (dyn), stimulate feeding when injected centrally in the rat. Norbinaltorphimine (norBNI, 25 nmol) reduced the feeding response to NPY (2.4 nmol) by 67% (P < 0.02). An additive effect of dynorphin and NPY was seen on food intake (saline 0.8 +/- 0.1, dyn 1.9 +/- 0.4, NPY 6.1 +/- 1.4, dyn and NPY 9.7 +/- 2.2). A component of NPY-induced feeding may be mediated by kappa-opioid neuronal systems.

MeSH terms

Animals
Cerebral Ventricles / drug effects
Cerebral Ventricles / physiology*
Drug Administration Schedule
Dynorphins / administration & dosage
Dynorphins / pharmacology*
Feeding Behavior / drug effects*
Injections, Intraventricular
Male
Naltrexone / administration & dosage
Naltrexone / analogs & derivatives*
Naltrexone / pharmacology
Neuropeptide Y / administration & dosage
Neuropeptide Y / pharmacology*
Rats
Rats, Wistar
Receptors, Opioid, kappa / antagonists & inhibitors*

Substances

Neuropeptide Y
Receptors, Opioid, kappa
norbinaltorphimine
Naltrexone
Dynorphins