Abstract
Rats, with chronic cannula placed bilaterally in the amygdala, received infusions of the N-methyl-D-aspartate (NMDA) receptor antagonist D,L-2-amino-5-phosphonovaleric acid (APV) before contextual Pavlovian fear conditioning. Administration of APV to the basolateral nucleus prevented acquisition of fear. Central nucleus infusions had no effect. It is concluded that an NMDA-mediated process near the basolateral region of the amygdala (e.g., lateral or basolateral nucleus) is essential for the learning of fear.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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2-Amino-5-phosphonovalerate / pharmacology*
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Amygdala / drug effects*
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Amygdala / physiology
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Animals
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Association Learning / drug effects*
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Association Learning / physiology
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Conditioning, Classical / drug effects*
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Conditioning, Classical / physiology
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Electroshock
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Exploratory Behavior / drug effects
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Exploratory Behavior / physiology
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Fear / drug effects*
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Fear / physiology
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Female
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Motor Activity / drug effects
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Motor Activity / physiology
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Rats
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
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Receptors, N-Methyl-D-Aspartate / physiology
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Social Environment
Substances
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Receptors, N-Methyl-D-Aspartate
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2-Amino-5-phosphonovalerate