The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotoninergic neurons in rats is attenuated by lesion of the frontal cortex

Neuropharmacology. 1994 May;33(5):709-13. doi: 10.1016/0028-3908(94)90177-5.

Abstract

The dose-response inhibitory effect of 8-OH-DPAT on the firing rate of dorsal raphe serotoninergic neurons was shifted 10-fold to the right after acute fronto-cortical deafferentation. This finding suggests that the inhibitory effect of 8-OH-DPAT on the dorsal raphe firing rate might be mediated indirectly by the frontal cortex.

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology*
  • Animals
  • Frontal Lobe / cytology
  • Frontal Lobe / physiology*
  • Male
  • Neurons / drug effects*
  • Raphe Nuclei / anatomy & histology
  • Raphe Nuclei / cytology
  • Raphe Nuclei / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin / physiology*

Substances

  • Serotonin
  • 8-Hydroxy-2-(di-n-propylamino)tetralin