Abstract
Many receptors that sense the environment effect intracellular regulation through stimulation of heterotrimeric G proteins and the consequences thereof. While prominence was originally given to the alpha-subunits of G proteins as the pathway for downstream regulation, very active roles for the beta gamma-subunits have emerged in the past year. Recent experiments highlight the versatility of beta gamma-subunits in these regulatory pathways, but also emphasize some fundamental questions that remain.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenylyl Cyclases / metabolism
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Animals
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GTP Phosphohydrolases / metabolism
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GTP-Binding Proteins / chemistry*
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GTP-Binding Proteins / metabolism*
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GTPase-Activating Proteins
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Humans
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Macromolecular Substances
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Models, Biological
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Models, Structural
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Proteins / metabolism
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Signal Transduction*
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Type C Phospholipases / metabolism
Substances
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GTPase-Activating Proteins
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Macromolecular Substances
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Proteins
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Type C Phospholipases
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GTP Phosphohydrolases
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GTP-Binding Proteins
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Adenylyl Cyclases