Abstract
This study images dopamine release in response to a neurochemically specific challenge with the psychostimulant drug methylphenidate. Changes in synaptic dopamine induced by methylphenidate were evaluated with positron emission tomography and [11C]raclopride, a D2 receptor radioligand that is sensitive to endogenous dopamine. Methylphenidate significantly decreased striatal [11C]raclopride binding. The decrease was variable and was negatively correlated with age. Mood and anxiety at baseline, were also correlated with methylphenidate-induced DA changes. This strategy provides a tool to investigate the responsiveness of the dopamine system in the normal and diseased human brain and to investigate the neurochemical correlates of behavior.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Affect / physiology
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Anxiety / metabolism
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Basal Ganglia / diagnostic imaging
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Basal Ganglia / metabolism
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Binding, Competitive / drug effects
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Brain / diagnostic imaging
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Brain / drug effects
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Brain / metabolism*
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Brain Chemistry / drug effects
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Brain Chemistry / physiology*
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Cerebrovascular Circulation / physiology
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Dopamine / metabolism*
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Dopamine D2 Receptor Antagonists*
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Humans
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Male
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Methylphenidate / pharmacokinetics
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Methylphenidate / pharmacology
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Middle Aged
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Neostriatum / diagnostic imaging
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Neostriatum / drug effects
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Neostriatum / metabolism
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Raclopride
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Salicylamides / pharmacokinetics*
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Synapses / metabolism
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Tomography, Emission-Computed
Substances
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Dopamine D2 Receptor Antagonists
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Salicylamides
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Methylphenidate
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Raclopride
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Dopamine