Grooming and vacuous chewing induced by SK&F 83959, an agonist of dopamine 'D1-like' receptors that inhibits dopamine-sensitive adenylyl cyclase

Eur J Pharmacol. 1993 Mar 30;234(1):135-6. doi: 10.1016/0014-2999(93)90718-w.

Abstract

The benzazepine SK&F 83959 demonstrates high affinity for dopamine D1 receptors and potently inhibits the stimulation of adenylyl cyclase by dopamine. This compound induced the same intense grooming behaviour identified previously as a characteristic response to typical dopamine D1 receptor agonists such as SK&F 77434 that stimulate adenylyl cyclase; it also induced vacuous chewing. These findings constitute direct evidence for a behaviourally relevant subtype of 'D1-like' receptor that is not linked to adenylyl cyclase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / analogs & derivatives*
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
  • Adenylyl Cyclase Inhibitors*
  • Animals
  • Behavior, Animal / drug effects*
  • Dopamine / physiology
  • Dopamine Agents / pharmacology*
  • Enzyme Activation / drug effects
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D1 / drug effects*

Substances

  • Adenylyl Cyclase Inhibitors
  • Dopamine Agents
  • Receptors, Dopamine D1
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • SK&F 83959
  • Dopamine