Abstract
The benzazepine SK&F 83959 demonstrates high affinity for dopamine D1 receptors and potently inhibits the stimulation of adenylyl cyclase by dopamine. This compound induced the same intense grooming behaviour identified previously as a characteristic response to typical dopamine D1 receptor agonists such as SK&F 77434 that stimulate adenylyl cyclase; it also induced vacuous chewing. These findings constitute direct evidence for a behaviourally relevant subtype of 'D1-like' receptor that is not linked to adenylyl cyclase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / analogs & derivatives*
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
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Adenylyl Cyclase Inhibitors*
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Animals
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Behavior, Animal / drug effects*
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Dopamine / physiology
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Dopamine Agents / pharmacology*
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Enzyme Activation / drug effects
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Male
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Rats
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Rats, Sprague-Dawley
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Receptors, Dopamine D1 / drug effects*
Substances
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Adenylyl Cyclase Inhibitors
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Dopamine Agents
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Receptors, Dopamine D1
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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SK&F 83959
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Dopamine