Abstract
The impact of cocaine self-administration on the expression of striatal preprodynorphin and c-fos mRNA was examined with in situ hybridization histochemistry. Cocaine significantly increased preprodynorphin mRNA in the dorsal, but not ventral, striatum. Expression of c-fos mRNA in cocaine-administering rats did not differ from that in controls in all structures examined. These results indicate that the expression of preprodynorphin, but not c-fos, is upregulated in rat striatum as a consequence of cocaine self-administration. Furthermore, these data indicate that the regulation of preprodynorphin is dissociable from the expression of c-fos in rats exposed to repeated doses of cocaine.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Cell Nucleus / drug effects
-
Cell Nucleus / metabolism
-
Cocaine / administration & dosage
-
Cocaine / pharmacology*
-
Corpus Striatum / drug effects
-
Corpus Striatum / metabolism*
-
Dynorphins / biosynthesis*
-
Gene Expression / drug effects
-
Genes, fos*
-
In Situ Hybridization
-
Male
-
Neurons / drug effects
-
Neurons / metabolism
-
Nucleus Accumbens / drug effects
-
Nucleus Accumbens / metabolism
-
Protein Precursors / biosynthesis*
-
RNA, Messenger / biosynthesis*
-
Rats
-
Rats, Wistar
-
Reinforcement Schedule
-
Self Administration
Substances
-
Protein Precursors
-
RNA, Messenger
-
pre-prodynorphin
-
Dynorphins
-
Cocaine