Synaptic vesicle proteins and regulated exocytosis

J Cell Sci Suppl. 1993:17:75-9. doi: 10.1242/jcs.1993.supplement_17.11.

Abstract

The recent identification of novel proteins associated with the membranes of synaptic vesicles has ignited the field of molecular neurobiology to probe the function of these molecules. Evidence is mounting that the vesicle proteins vamp (synaptobrevin), rab3A, synaptophysin, synaptotagmin (p65) and SV2 play an important role in regulated exocytosis, by regulating neurotransmitter uptake, vesicle targeting and fusion with the presynaptic plasma membrane.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium-Binding Proteins*
  • Cell Polarity
  • Exocytosis / physiology*
  • GTP-Binding Proteins / metabolism
  • Membrane Glycoproteins / metabolism
  • Membrane Proteins / metabolism
  • Models, Neurological
  • Nerve Tissue Proteins / metabolism*
  • R-SNARE Proteins
  • Synaptic Vesicles / metabolism*
  • Synaptic Vesicles / ultrastructure
  • Synaptophysin / metabolism
  • Synaptotagmin I
  • Synaptotagmins
  • rab3 GTP-Binding Proteins

Substances

  • Calcium-Binding Proteins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • R-SNARE Proteins
  • Synaptophysin
  • Synaptotagmin I
  • Synaptotagmins
  • GTP-Binding Proteins
  • rab3 GTP-Binding Proteins
  • Calcium