Abstract
Immunocytochemical techniques were used to study the colocalization of proto-oncogene c-fos protein (Fos)-like immunoreactivity and of glucocorticoid receptor immunoreactivity in the spinal cord dorsal horn of adult male rats after nociceptive stimulation. About 5-10% of the stimulus evoked Fos-immunoreactive profiles colocalized glucocorticoid receptor immunoreactivity. The results suggest the possibility of a corticosteroid action in a small neuronal population of the dorsal horn implicated in processing nociceptive inputs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Electric Stimulation
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Fluorescent Antibody Technique
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Gene Expression
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Genes, fos*
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Immunohistochemistry
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Male
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Neurons / metabolism*
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Neurons / physiology
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Pain / metabolism
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Pain / physiopathology
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Proto-Oncogene Proteins c-fos / analysis
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Proto-Oncogene Proteins c-fos / biosynthesis*
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Rats
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Rats, Sprague-Dawley
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Receptors, Glucocorticoid / analysis
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Receptors, Glucocorticoid / biosynthesis*
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Sciatic Nerve / physiology
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Spinal Cord / metabolism*
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Spinal Cord / physiology
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Spinal Cord / physiopathology
Substances
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Proto-Oncogene Proteins c-fos
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Receptors, Glucocorticoid