Abstract
Quantitative in situ hybridization analysis of catalytic (trkB TK+) and non-catalytic (trkB TK-) trkB mRNAs in the postnatal rat brain demonstrated regional differences in expression and revealed transient increases in trkB TK+ expression. Hybridization of trkB TK+ mRNA was observed in thalamic nuclei between P4 and P8, but not in the adult. In hippocampal structures, transient elevations of trkB TK+ mRNA were apparent between P13 and P17. In contrast, there was a gradual developmental increase in trkB TK- mRNA expression in the hippocampus.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / anatomy & histology
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Brain / growth & development*
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Brain Chemistry / physiology*
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Female
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Hippocampus / growth & development
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Hippocampus / metabolism
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In Situ Hybridization
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Nerve Growth Factors / biosynthesis
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Nerve Tissue Proteins / biosynthesis
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Neurotrophin 3
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Pregnancy
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RNA Probes
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RNA, Messenger / biosynthesis*
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Rats
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Rats, Sprague-Dawley
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Receptor Protein-Tyrosine Kinases / biosynthesis*
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Sulfur Radioisotopes
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Thalamic Nuclei / growth & development
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Thalamic Nuclei / metabolism
Substances
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Nerve Growth Factors
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Nerve Tissue Proteins
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Neurotrophin 3
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RNA Probes
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RNA, Messenger
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Sulfur Radioisotopes
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neurotrophin 5
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Receptor Protein-Tyrosine Kinases
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neurotrophin 4