Abstract
Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801), which also blocked LTP induction, and by sodium pentobarbital, which shortens LTP persistence. These results suggest that BDNF may participate in the NMDA-receptor mediated cascade of events that result in LTP stabilization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / drug effects
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Brain / metabolism*
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Brain-Derived Neurotrophic Factor
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Dizocilpine Maleate / pharmacology
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Evoked Potentials / drug effects
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Gene Expression / drug effects
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In Situ Hybridization
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Long-Term Potentiation* / drug effects
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Male
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Nerve Growth Factors / biosynthesis*
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Nerve Tissue Proteins / biosynthesis*
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RNA, Messenger / biosynthesis*
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Rats
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Rats, Sprague-Dawley
Substances
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Brain-Derived Neurotrophic Factor
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Nerve Growth Factors
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Nerve Tissue Proteins
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RNA, Messenger
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Dizocilpine Maleate