Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced parkinsonism

MeSH terms

• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / pharmacokinetics
• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / pharmacology*
• Animals
• Brain / drug effects*
• Brain / physiopathology
• Calcium / physiology*
• Calcium Channels / drug effects
• Calcium Channels / physiology
• Cell Death / drug effects
• Cell Death / physiology
• Corpus Striatum / drug effects
• Corpus Striatum / physiopathology
• Dopamine / metabolism*
• Free Radicals
• Hydroxides / metabolism*
• Hydroxyl Radical
• Iron / physiology
• Monoamine Oxidase / physiology
• Nerve Degeneration / drug effects
• Nerve Degeneration / physiology
• Neural Pathways / drug effects
• Neural Pathways / physiopathology
• Oxidation-Reduction
• Parkinson Disease, Secondary / chemically induced*
• Parkinson Disease, Secondary / physiopathology
• Potassium / physiology
• Potassium Channels / drug effects
• Potassium Channels / physiology
• Rats
• Substantia Nigra / drug effects*
• Substantia Nigra / physiopathology