Abstract
The proteins Grb2-Sem-5, Shc and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2-Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand-activated tyrosine kinase receptors which bind Grb2-Sem-5, and with the Grb2-Sem-5 binding protein, Shc. Ectopic expression of Drosophila Sos stimulates morphological transformation of rodent fibroblasts. These data define a pathway by which tyrosine kinases act through Ras to control cell growth and differentiation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Amino Acid Sequence
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Animals
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Base Sequence
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Caenorhabditis elegans
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Cell Differentiation*
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Cells, Cultured
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Cloning, Molecular
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DNA, Single-Stranded
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Drosophila
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ErbB Receptors / metabolism
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GRB2 Adaptor Protein
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Humans
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Membrane Proteins / metabolism*
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Mice
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Molecular Sequence Data
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Protein Binding
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Protein-Tyrosine Kinases / metabolism*
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Proteins / metabolism*
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Proto-Oncogene Proteins p21(ras) / metabolism*
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Rats
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Signal Transduction*
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Son of Sevenless Proteins
Substances
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Adaptor Proteins, Signal Transducing
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DNA, Single-Stranded
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GRB2 Adaptor Protein
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GRB2 protein, human
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Grb2 protein, mouse
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Grb2 protein, rat
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Membrane Proteins
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Proteins
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Son of Sevenless Proteins
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ErbB Receptors
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Protein-Tyrosine Kinases
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HRAS protein, human
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Proto-Oncogene Proteins p21(ras)