Abstract
This study examined whether damage to dopamine (DA) nerve terminals via inhibition of energy metabolism in the striatum would result in the retrograde loss of cell bodies in the substantia nigra. Infusion of 2 micromol malonate into the left striatum of rats resulted in a 67% loss of striatal DA and a 40% loss of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra. No change in the number of Nissl-positive-TH-negative neurons was observed. These findings demonstrate the retrograde destruction of DA cell bodies in the substantia nigra resulting from energy impairment at their terminal projection site.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism*
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Corpus Striatum / pathology
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Dopamine / metabolism*
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Energy Metabolism / drug effects
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Energy Metabolism / physiology*
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Functional Laterality
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Infusions, Parenteral
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Male
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Malonates / administration & dosage
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Malonates / toxicity*
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Nerve Endings / drug effects
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Nerve Endings / physiology
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Neurons / drug effects
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Neurons / metabolism
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Neurons / pathology
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Rats
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Rats, Sprague-Dawley
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Substantia Nigra / drug effects
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Substantia Nigra / pathology*
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Tyrosine 3-Monooxygenase / analysis
Substances
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Malonates
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malonic acid
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Tyrosine 3-Monooxygenase
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Dopamine