Abstract
Receptor-like protein tyrosine phosphatase beta (RPTP beta) shows structural and functional similarity to cell adhesion molecules (CAMs). It binds to several neuronal CAMs and extracellular matrix (ECM) proteins that combine to form cell-recognition complexes. Here, the authors discuss the implications of such complexes for intercellular signaling, and the regulation of RPTP activity by cell-cell and cell-ECM contact.
MeSH terms
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Animals
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Cell Communication
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Extracellular Matrix / metabolism
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Humans
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Ligands
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / metabolism*
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Nervous System / cytology
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Nervous System / metabolism
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Neural Cell Adhesion Molecules / metabolism
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Protein Tyrosine Phosphatases / chemistry
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Protein Tyrosine Phosphatases / metabolism*
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Receptor-Like Protein Tyrosine Phosphatases, Class 5
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Signal Transduction
Substances
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Ligands
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Nerve Tissue Proteins
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Neural Cell Adhesion Molecules
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PTPRZ1 protein, human
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Protein Tyrosine Phosphatases
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Receptor-Like Protein Tyrosine Phosphatases, Class 5