Self-sustaining status epilepticus after brief electrical stimulation of the perforant path

Brain Res. 1998 Aug 10;801(1-2):251-3. doi: 10.1016/s0006-8993(98)00606-4.

Abstract

We examined the duration of intermittent perforant path stimulation (PPS) needed to induce self-sustaining status epilepticus (SSSE) in rats. Seven-minute PPS did not induce SSSE. Some rats receiving 15 min and all animals after 30 min PPS developed SSSE that continued for hours. The animals killed 3 days after SSSE showed extensive neuronal damage. Those which were allowed to survive for 6 weeks after SSSE displayed spontaneous seizures.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / pathology
  • Brain / physiology
  • Electric Stimulation
  • Electrodes, Implanted
  • Electroencephalography
  • Male
  • Neurons / pathology
  • Neurons / physiology
  • Perforant Pathway / physiology*
  • Rats
  • Rats, Wistar
  • Seizures / physiopathology
  • Status Epilepticus / physiopathology*
  • Time Factors
  • Wakefulness