NMDA-Induced intrinsic voltage oscillations depend on L-type calcium channels in spinal motoneurons of adult turtles

J Neurophysiol. 1998 Dec;80(6):3380-2. doi: 10.1152/jn.1998.80.6.3380.

Abstract

NMDA-induced intrinsic voltage oscillations depend on L-type calcium channels in spinal motoneurons of adult turtles. J. Neurophysiol. 80: 3380-3382, 1998. In a slice preparation from adult turtles, bath-applied N-methyl-D-aspartate (NMDA) induced rhythmic activity in spinal motoneurons. The underlying intrinsic oscillation in membrane potential was revealed in the presence of tetrodotoxin (TTX). NMDA-induced rhythmicity, in the presence or absence of TTX, was abolished or reduced by NMDA receptor antagonists and by three different classes of antagonists for L-type calcium channels. It is suggested that both NMDA receptor channels and L-type calcium channels contribute to NMDA-induced intrinsic oscillations in mature spinal motoneurons.

MeSH terms

  • Animals
  • Calcium Channel Blockers / pharmacology
  • Calcium Channels / physiology*
  • Excitatory Amino Acid Antagonists / pharmacology
  • In Vitro Techniques
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Motor Neurons / drug effects
  • Motor Neurons / physiology*
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Receptors, N-Methyl-D-Aspartate / physiology*
  • Spinal Cord / cytology*
  • Spinal Cord / drug effects
  • Spinal Cord / physiology*
  • Tetrodotoxin / pharmacology
  • Turtles / physiology*

Substances

  • Calcium Channel Blockers
  • Calcium Channels
  • Excitatory Amino Acid Antagonists
  • Receptors, N-Methyl-D-Aspartate
  • Tetrodotoxin