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BACE (beta-secretase) modulates the processing of APLP2 in vivo.
Pastorino L, Ikin AF, Lamprianou S, Vacaresse N, Revelli JP, Platt K, Paganetti P, Mathews PM, Harroch S, Buxbaum JD. Pastorino L, et al. Among authors: ikin af. Mol Cell Neurosci. 2004 Apr;25(4):642-9. doi: 10.1016/j.mcn.2003.12.013. Mol Cell Neurosci. 2004. PMID: 15080893
Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding.
Ikin AF, Causevic M, Pedrini S, Benson LS, Buxbaum JD, Suzuki T, Lovestone S, Higashiyama S, Mustelin T, Burgoyne RD, Gandy S. Ikin AF, et al. Mol Neurodegener. 2007 Dec 9;2:23. doi: 10.1186/1750-1326-2-23. Mol Neurodegener. 2007. PMID: 18067682 Free PMC article.