Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from
Archea to man. Thioredoxins, with a dithiol/disulfide active site (CGPC) are the major cellular …

Thioredoxin is known as a hydrogen donor for ribonucleotide reductase, the essential
enzyme providing deoxyribonucleotides for DNA replication (1-4). Characterization of viable …

This review summarizes current knowledge about thioredoxin and related topics, with
emphasis on the best-characterized systems. The literature on thioredoxin covers a fascinating …

Publisher Summary This chapter summarizes current methods to determine Trx and thioredoxin
reductase (TR). Thioredoxin (Trx) is a small (Mr 12,000) multifunctional and ubiquitous …

The thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR),
and thioredoxin, is a key antioxidant system in defense against oxidative stress through its …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

In Escherichia coli, two pathways use NADPH to reduce disulfide bonds that form in some
cytoplasmic enzymes during catalysis: the thioredoxin system, which consists of thioredoxin …

Thioredoxin from Escherichia coli was shown to catalyze the reduction of insulin disulfides
by dithiothreitol. A quantitative assay was developed which measures the rate of insulin …

This study examines the basis of resistance and sensitivity of normal and transformed cells
to histone deacetylase inhibitor (HDACi)-induced cell death, specifically the role of caspases …

Mikaela Luthman and Arne Holmgren* abstract: A reproducible scheme has been developed
for the preparation of rat liver thioredoxin and thioredoxin reductase (EC 1.6. 4.5) by using …