Immunological mechanisms have come into the focus of current translational stroke research,
and the modulation of neuroinflammatory pathways has been identified as a promising …

Despite their delayed recruitment in the brain, Treg have been found, in both depletion and
therapeutic paradigms (see below), to influence stroke outcomes within the first days after …

Highlights • The microbiome-gut-brain axis plays a crucial role in neurological disorders. •
Gut dysbiosis leads to increased inflammatory reactions in stroke, PD and AD. • Microbial …

Systemic and local inflammatory processes have a key, mainly detrimental role in the
pathophysiology of ischemic stroke. Currently, little is known about endogenous counterregulatory …

Acute brain ischemia induces a local neuroinflammatory reaction and alters peripheral
immune homeostasis at the same time. Recent evidence has suggested a key role of the gut …

Microglia are the main immune cells in the brain and have roles in brain homeostasis and
neurological diseases. Mechanisms underlying microglia–neuron communication remain …

T lymphocytes are increasingly recognized as key modulators of detrimental inflammatory
cascades in acute ischaemic stroke, but the potential of T cell-targeted therapy in brain …

Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer’s
disease (AD) progression. However, the mechanisms of microbiome–brain interaction in …

Abstract Analysis of entire transparent rodent bodies after clearing could provide holistic
biological information in health and disease, but reliable imaging and quantification of …

The CNS is ensheathed by the meninges and cerebrospinal fluid, and recent findings suggest
that these CNS-associated border tissues have complex immunological functions. Unlike …