The role of Müller glia and microglia in glaucoma
R Seitz, A Ohlmann, ER Tamm - Cell and tissue research, 2013 - Springer
Cells of Müller glia and microglia react to neuronal injury in glaucoma. The change to a
reactive phenotype initiates signaling cascades that may serve a neuroprotective role, but may …
reactive phenotype initiates signaling cascades that may serve a neuroprotective role, but may …
Norrin: molecular and functional properties of an angiogenic and neuroprotective growth factor
A Ohlmann, ER Tamm - Progress in retinal and eye research, 2012 - Elsevier
Norrin is a secreted signaling molecule with structural and functional characteristics of an
autocrine and/or paracrine acting growth factor. In the eye, Norrin is constitutively expressed in …
autocrine and/or paracrine acting growth factor. In the eye, Norrin is constitutively expressed in …
Norrin mediates neuroprotective effects on retinal ganglion cells via activation of the Wnt/β-catenin signaling pathway and the induction of neuroprotective growth …
…, T Seibuchner, ER Tamm, A Ohlmann - Journal of …, 2010 - Soc Neuroscience
Norrin is a secreted protein that binds to frizzled 4 and controls development of capillaries in
retina and inner ear. We provide evidence that Norrin has distinct neuroprotective …
retina and inner ear. We provide evidence that Norrin has distinct neuroprotective …
Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice
A Ohlmann, M Scholz, A Goldwich… - Journal of …, 2005 - Soc Neuroscience
Norrie disease is an X-linked retinal dysplasia that presents with congenital blindness,
sensorineural deafness, and mental retardation. Norrin, the protein product of the Norrie disease …
sensorineural deafness, and mental retardation. Norrin, the protein product of the Norrie disease …
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-β1 and dexamethasone in vitro
C Flügel-Koch, A Ohlmann, R Fuchshofer… - Experimental eye …, 2004 - Elsevier
Transforming growth factor-β2 (TGF-β2) is elevated in the aqueous humor of patients with
primary open-angle glaucoma (POAG), and high levels of TGF-β2 are thought to contribute to …
primary open-angle glaucoma (POAG), and high levels of TGF-β2 are thought to contribute to …
Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice
A Ohlmann, R Seitz, B Braunger, D Seitz… - Journal of …, 2010 - Soc Neuroscience
Norrin is a secreted protein that is involved in retinal angiogenesis and activates the Wnt-signaling
pathway. We studied the role of Norrin in microvascular endothelial cells in vitro, and …
pathway. We studied the role of Norrin in microvascular endothelial cells in vitro, and …
[HTML][HTML] Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities
DC Baulmann, A Ohlmann, C Flügel-Koch… - Mechanisms of …, 2002 - Elsevier
The development of the chamber angle was studied in the eyes of heterozygous Pax6 lacZ/+
mutant mice (Nature 387 (1997) 406). Mutations in PAX6 cause aniridia, a condition that is …
mutant mice (Nature 387 (1997) 406). Mutations in PAX6 cause aniridia, a condition that is …
Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage
BM Braunger, A Ohlmann, M Koch, N Tanimoto… - Neurobiology of …, 2013 - Elsevier
Norrin is a retinal signaling molecule which is expressed in Müller glia and binds to Frizzled-4
to activate canonical Wnt/β-catenin signaling. Norrin is part of an essential signaling …
to activate canonical Wnt/β-catenin signaling. Norrin is part of an essential signaling …
[HTML][HTML] Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3
…, M Seeliger, E Tamm, A Ohlmann… - … & visual science, 2008 - arvojournals.org
purpose. Tissue inhibitor of metalloprotease (TIMP)-3 is an inhibitor of matrix metalloprotease
(MMP) and regulates angiogenesis. In the eye, TIMP3 is tightly associated with Bruch’s …
(MMP) and regulates angiogenesis. In the eye, TIMP3 is tightly associated with Bruch’s …
Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application
K Pollinger, R Hennig, A Ohlmann… - Proceedings of the …, 2013 - National Acad Sciences
To date, diseases affecting vascular structures in the posterior eye are mostly treated by
laser photocoagulation and multiple intraocular injections, procedures that destroy healthy …
laser photocoagulation and multiple intraocular injections, procedures that destroy healthy …